8th International Conference and Exhibition on Natural & Alternative Medicine September 25-27, 2017 Dubai, UAE

Chair

Lloyd Jenkins

Budwig Cancer Clinic, Spain

Session Introduction

Zehra Gok Metin

Hacettepe University, Turkey

Title: Aromatherapy and refl exology experiences of Rheumatoid Arthritis patients

Biography:

Zehra Gok Metin has completed her PhD in 2015 from Hacettepe University and stayed almost one year at University of Alabama at Birmingham for Post-doctoral studies. She is an Instructor at Hacettepe University Faculty of Nursing. She is working on symptom management especially for pain for five years. She has several publications in reputed journals and has been serving as a reviewer for reputed journals.

Abstract:

Statement of the Problem: Nonpharmacological interventions such as aromatherapy and reflexology have increasingly been used to manage symptoms among patients with rheumatoid arthritis (RA). There have been quantitative studies, have shown that aromatherapy and reflexology may reduce psychological distress and enhance symptom control in RA patients). However, little is known about the personal meanings patients associate with these therapies. Therefore, present study explored the patients' experiences of aromatherapy and reflexology by using face to face interview. Methodology & Theoretical Orientation: Totally 34 RA patients who received aromatherapy massage (n=17) or reflexology (n=17) constituted the study sample. “Patients’ demographic questionnaire” and “Individual experiences form for aromatherapy and reflexology” were used to record patients’ statements during face to face interviews. Patients’ statements on aromatherapy and reflexology were categorized based on similarity and presented by using percentages.  Findings: Patients’ mean age was 54.4±1.2 years and the great majority of the patients were female (88.2%). Regarding patients’ experiences on aromatherapy, all subjects stated that walked more easily, wanted to sleep immediately after each aromatherapy session, felt more comfortable, 94.1% of patients’ had relief of daily functions and movements, felt improvements in vitality, energy capacity and mood. 76.5% of participants stated return to hobbies and activities they enjoy after aromatherapy sessions. As for reflexology, all participants reported that return to hobbies and activities they enjoy, felt improvements in vitality, energy capacity and mood. 94.1% of patients’ stated that walked more easily, 88.2% had relief of daily functions and movements, and 82.4% fulfilled house work without difficulty. Conclusion & Significance: Consistent with studies reporting cancer patients’ perceptions, RA individuals in this study specified that aromatherapy and reflexology had beneficial effects to perform their activities of daily living easily, felt self-empowered, having lower symptom burden, and depressive mood.

Tu Feng

School of Chinese Medicine Hong Kong Baptist University, Hong Kong

Title: Comparison of Effectiveness of Acupuncture thrust-debonding and three Acupoints in Patients shoulder with Subacromial impingement syndrome: A Randomized Clinical Trial

Biography:

Tu Feng, Principal Lecturer of the Teaching and Researching Division, School of Chinese Medicine. Feng Tu won President’s Award for Outstanding Performance
in Teaching.

Abstract:

Objective: To explore therapeutic effect of acupuncture in treating Subacromial Impingement Syndrome (SIS), through the
comparison of effectiveness of thrust-debonding and three acupoints in patients shoulder.
Method: It is a randomized clinical trial. This study was carried out with 40 patients, who had SIS. Observation group (n=20)
had received needle thrust-debonding program in subacromial space, Control group (n=20) was treated with needling three
acupoints, which are Jianyu (LI 15), Jianliao (SJ 14), Tianzong (SI 11). All patients received one treatment sessions for four
weeks (once a week).
Outcome Measures: The effects were observed after four weeks of treatment, according to the standard of TCM Syndrome
Diagnostic efficacy. Pain was evaluated using Constant-Murley Score (CMS) for 1st, 2nd and 4th week.
Results: Cure rate after 4 weeks in observation group was 90%, higher than 55% in control group with statistical meaning
(P<0.05). The treatment program of observation group were found to be significantly effective in reduction of pain with CMS
(P<0.05) in different period before and after treatment, but the control group showed no significantly effective (P>0.05).
Conclusion: The results of this clinical trial demonstrate that the thrust-debonding program may be the first treatment choice
for therapist in managing SAIS.

Chanchal Garg

Maharshi Dayanand University, India

Title: Optimized Ionic Liquid-based Microwave Assisted Extraction of Piperine from Indian Ayurvedic Plant Piper nigrum

Biography:

Chanchal Garg completed masters at MDU Rohtak (Maharshi Dayanand University) in Harayana and presently she is working as Faculty of Pharmacy, in the Department of Pharmaceutical Sciences, Maharashi Dayanand University, India.

Abstract:

An optimized ionic liquid-based microwave assisted extraction (IL-MAE) method was developed for piperine from Piper nigrum using ionic liquid, 1-butyl-3-methyl-imidazolium chloride ([bmim]Cl) by response surface methodology. Variable microwave-assisted extraction parameters were selected as concentration of [bmim]Cl, extraction time and microwave power while solid-liquid ratio and extraction temperature were kept constant. Response surface methodology was applied for developing, improving and optimizing the process. A multivariate quadratic regression equation was obtained by central composite design. The 3D response surface curve and contour plots were obtained by variance of analysis (ANOVA). HPTLC was performed for quantitative and comparative analysis of piperine for IL-MAE with conventional methods. The optimum extraction conditions were 3.0 mol/L, microwave power 700 W, extraction time 9 min, extraction temperature 70 ºC, solid- liquid ratio 1:10. With this novel IL-MAE method, the yield of piperine is increased from 1.8% w/w in 7 days (maceration) and 2.03% in 3 hours (soxhlation) to 4.71% in 9 minutes (IL-MAE). Meanwhile, there was great reduction in the environmental pollution by using the green solvents/ionic liquids (ILs), which is a great benefit to all.

 

Munish Garg

Maharshi Dayanand University, India

Title: Development and Optimization of Boswellic acids loaded proniosomal Gel

Biography:

Munish Garg is presently working as a Professor and Head of the Department of Pharmaceutical Sciences, Maharshi Dayanand University, India. He has about 17 years of professional experience in the field of Academics, Research and Administration. Previously he has worked as an Assistant Director, All India Council for Technical Education, New Delhi where he has contributed in the quality control of technical education. His research area is Quality Control and Standardization of Herbal Plants and Formulations for Safety and Efficacy. He has about 70 research papers, 50 presentations, 150 scientific abstracts and financial grant of about Rs. 1 Crore from different Government funding agencies to his credit. He is in the panel of several Government bodies for planning and execution of pharmacy and technical education in India.

Abstract:

Boswellic acids (BAs) are isolated from oleo gum of Boswellia serrata Triana & Planch. (Family: Burseraceae) and are mainly used as potential anti-inflammatory, hypolipidemic, immunomodulatory and antitumor agents. Pharmacokinetic investigations of boswellic acids uncover its poor bioavailability through digestive system thus necessitates an improved
therapeutic response which can possibly be achieved by developing formulations through novel delivery system. The present study was conducted to design topical boswellic acids loaded proniosomal gel for the management of inflammatory disorders with enhanced bioavailability. Non-ionic surfactant vesicles were prepared using the coacervation phase separation method.
A central composite design was employed to statistically optimize formulation variables using Design-Expert software. Three independent variables were evaluated: Amount of surfactant (X1), amount of soyalecithin (X2), and amount of cholesterol (X3). The encapsulation efficiency percentage (Y1) and particle size (Y2) were selected as dependent variables. The optimum
formulation (F10) displayed spherical bi-layered vesicles under transmission electron microscopy (TEM) with optimum particle size of 707.9 nm and high entrapment efficiency as 98.52%. In vitro skin permeation study demonstrated the most sustained release of 84.83±0.153 mg/cm2 in 24 hours. Antiinflammatory activity of the gel showed a significant (p<0.001)
higher percentage inhibition as compared to the marketed gel at the same dose. The present study exhibited that boswellic acids loaded proniosomal gel was better in terms of absorption, bioavailability and release kinetics.

Chair

Tu Feng

School of Chinese Medicine Hong Kong Baptist University, Hong Kong

Chair

Chanchal Garg,

Maharshi Dayanand University, India

Chair

Munish Garg

Maharshi Dayanand University, India

Chair

Pierluigi Pompei

University of Camerino, Italy

Session Introduction

Slobodan Dunjić

Center for Integrative Procedures and Supplements, Serbia

Title: Personal-holistic approach should be used additionally to conventional therapy in treatment of colorectal cancer – case report

Biography:

Slobodan Dunjic is a Medical Doctor, completed his Master of Science in the field of Rheumatology. He is the Founder of the Center for Integrative Procedures and Supplements “Dr Dunjić”, based in Belgrade, Serbia. In professional career, he is primarily oriented towards personal and holistic approach in healing the patients suffering from various diseases. He strongly believes that we need to treat a person suffering from diseases, rather than disease itself. He is also the Co-Founder of association for personal holistic approach in healing the patients in Serbia and by activity of this association; he provides continuing medical education to all medical professionals. He has published more than 25 papers in various journals at national and international level.

Abstract:

For the great majority of people, the major factor that increases a person’s risk for colorectal cancer is increasing age. Risk increases dramatically after age 50 years and 90% of all colorectal cancers are diagnosed after this age. The risk factors are numerous such as the history of colorectal cancers in first-degree relatives, presence of adenomas, ovarian cancer, inflammatory bowel disease etc. The aim of this paper is to present a case report showing that personal holistic approach in treatment of colorectal cancer additionally to standard therapy resulted in excellent outcome. 34 year old female patient noticed changes in bowel movements and the presence of blood in the stool during March of 2016. Immediately she visited her doctor. All necessary examinations were done (laboratory test, physical exam, digital rectal exam, fecal occult blood exam and colonoscopy). Adenocarcinoma of rectum which invaded submucosa was diagnosed. CT scan and magnetic resonance imaging (MRI) revealed enlarged lymphatic nodes in pelvic region with no presence of distant metastasis. 25 cycles of irradiation and 2 cycles of chemotherapy were administered. Following that, she was told she would be operated. Additionally to this treatment, she was subjected to personalized holistic treatment in three phases: (1) Detoxification of body, (2) Supplementation with minerals/trace elements/omega-3 fatty acids etc., and (3) Improving lymphatic circulation. Muscle test was applied in order to determine if the body needs supplements and which one (this ensures that every person has its own therapy which is personally tailored according to his/her body needs and current health status). While irradiation and chemotherapy, she did not report significant side effects described in the literature. She was scheduled for operation during mid of November, 2016. All the exams done before the operation showed that there was no cancer and she was dismissed with no operation. This is an example how personal holistic approach used concomitant with standard therapy may be useful in treatment of cancer patients.

 

Dušan Vešović

Center for Integrative Procedures and Supplements, Serbia

Title: Personal-holistic approach in treatment of breast cancer additionally to conventional therapy – case report

Biography:

Dusan Vesovic is a Medical doctor possessing Doctorate of Medical Sciences in the field of Preventive Medicine (Occupational Medicine). He also works as the Professor of Occupational Medicine. He is orientated towards personal holistic approach in treating the patients. He deeply believes that the disease is a result of imbalance in human body and when we treat a patient, we need to re-establish homeostasis in his/her body. For that purpose, he believes that personalized therapy of whole body, including spirit and mind should be applied. He is also the Co-Founder of association for personal holistic approach in healing the patients in Serbia and by activity of this association; he provides continuing medical education to all medical professionals. He has published more than 100 papers in various journals at national and international level.

 

Abstract:

Nowadays, breast cancer is the second leading cause of cancer death in women (the first one is lung cancer). The chance that a woman will die from breast cancer is about 1 in 36 (about 3%). The aim of this paper is to present case-report showing that personal-holistic approach in treatment of breast cancer additionally to standard therapy resulted in excellent outcome. 54 year old female patient noticed changes in skin of left breast during spring time of 2015. Immediately she visited her doctor. All necessary examinations were done (laboratory test, physical exam, chest X-ray, ultrasound, scintigraphy, etc.). Upon biopsy, diagnosis of ductal mixed invasive carcinoma was established. Scintigraphy revealed distant metastasis in spine, bones of shoulders, jaws and bones of pelvic region. Tumor marker CA15-3 was extremely high. Patient was suggested to undergo eight cycles of chemotherapy and single shot irradiation therapy. No operation was suggested. Additionally to this treatment, she was subjected to personalized holistic treatment in three phases: (1) Detoxification of body, (2) Supplementation with minerals/trace elements/omega-3 fatty acids etc., and (3) Improving lymphatic circulation. Muscle test was applied in order to ensure that this patient will receive its own therapy which is personally tailored. While irradiation and chemotherapy, she did not have significant side effects described in the literature. Her overall health status was getting better and she was, nevertheless, operated in September of 2015. Two tumors were extracted, as well as, five tumors from Spencer flap. 17 lymph nodes from armpit were removed. All the time, she has been using conventional drugs concomitant with personalized therapy. She is well now and recent scintigraphy showed regression process in bones. This is an example how personal holistic approach used concomitant with standard therapy may be useful in treatment of cancer patients.

Subramaniam Ganesh

Indian Institute of Technology, India

Title: Neuroprotective mechanisms of Amalaki Rasayana (Ayurvedic Medicine): A study on a genetic mouse model of neurodegenerative disorder

Biography:

Subramaniam Ganesh is an Endowed Chair Professor at the Indian Institute of Technology Kanpur, has made pioneering contribution in the field by choosing to work on the fatal neurodegenerative disorder Lafora disease (LD), characterized by abnormal glycogen accumulation in neurons. His recent research interests are in elucidating the molecular basis of therapeutic properties of the Ayurvedic formulations; one of the traditional medicinal systems of India.

Abstract:

Neurodegenerative disorders have attracted a lot of attention due to their complex origin (genetic and environmental), irreversible disease progression and their increasing incident rate due to increased life expectancy as most of them are late onset disorders. Emerging concepts suggest that the neurodegeneration results from perturbations in a number of cellular processes, including the proteolytic, inflammatory, pro-survival and metabolic pathways, that they share similarities with the aging process and that restoring the homeostasis of critical cellular processes might protect the neurons. Indeed the Ayurvedic formulations, known as “Rasayanas” and “Bhasmas”, are thought to provide such holistic protection on the central nervous system, but the underlying mechanisms have not been dissected using appropriate model systems and their mode of actions are yet to be fully understood. Our group has been working on the Lafora disease (LD), a monogenic, progressive and fatal form of neurodegenerative disorder and the symptoms include epilepsy, ataxia, dysarthria, psychosis and cognitive deficits. The neuropathology of LD includes the formation of glycogen inclusions as Lafora bodies in the neurons, muscle and liver tissues. The LD animals replicate most of the phenotypic traits and studies have shown that perturbations in glycogen metabolic pathways, proteolytic pathways and mitochondrial homeostasis underlie the LD symptoms. The current work was to evaluate the effect of prolonged feeding of Amalaki Rasayana (a formulation with extracts of Emblica officinalis) on the disease phenotype (viz., epilepsy, ataxia and cognitive abilities), disease pathology (viz., Lafora bodies, neurodegeneration, neuronal growth and maturation) and on the cellular physiology (viz., glycogen metabolism, autophagy and proteasomal function, neuroinflammation and synaptic functions). We find that feeding of animals with Amalaki Rasayana significantly reduced the neuroinflamation, increased autophagy and decreased the severity of the drug-induced epilepsy in this LD model.

Chanchal Garg

Maharshi Dayanand University, India

Title: Role of Natural Antioxidants in the Oxidative Stress induced Skin Photoaging

Biography:

Chanchal Garg completed masters at MDU Rohtak (Maharshi Dayanand University) in Harayana and presently she is working as Faculty of Pharmacy, in the Department of Pharmaceutical Sciences, Maharashi Dayanand University, India.

Abstract:

An optimized ionic liquid-based microwave assisted extraction (IL-MAE) method was developed for piperine from Piper nigrum using ionic liquid, 1-butyl-3-methyl-imidazolium chloride ([bmim]Cl) by response surface methodology. Variable microwave-assisted extraction parameters were selected as concentration of [bmim]Cl, extraction time and microwave power while solid-liquid ratio and extraction temperature were kept constant. Response surface methodology was applied for developing, improving and optimizing the process. A multivariate quadratic regression equation was obtained by central composite design. The 3D response surface curve and contour plots were obtained by variance of analysis (ANOVA). HPTLC was performed for quantitative and comparative analysis of piperine for IL-MAE with conventional methods. The optimum extraction conditions were 3.0 mol/L, microwave power 700 W, extraction time 9 min, extraction temperature 70 ºC, solid- liquid ratio 1:10. With this novel IL-MAE method, the yield of piperine is increased from 1.8% w/w in 7 days (maceration) and 2.03% in 3 hours (soxhlation) to 4.71% in 9 minutes (IL-MAE). Meanwhile, there was great reduction in the environmental pollution by using the green solvents/ionic liquids (ILs), which is a great benefit to all.

Dania Al-Jaroudi

King Fahad Medical City, Saudi Arabia

Title: Myrrh for treatment of severe vulvar edema in ovarian hyperstimulation syndrome

Biography:

Dania Al-Jaroudi is currently working as a Consultant in Obstetrics and Gynecology and REI, Reproductive Endocrine and Infertility and minimally invasive surgery. She is also the Chairman of Grant Management Department at the Research Center, King Fahad Medical City, KSA. She is an Assistant Professor of King Saud Bin Abdulaziz University for Health Sciences from March 28, 2010 to till date. She has completed her MBBS from King Saud University in 1996 and her Residency training at King Fahad National Guard Hospital, Riyadh in 2001. She has obtained her Fellowship training in Reproductive Endocrine and Infertility in 2004 at McGill University in Canada. She has over 30 publications, published several articles in international peer review journals and has on-going research projects in collaboration with other physicians.

Abstract:

Ovarian hyperstimulation syndrome is an iatrogenic complication of assisted reproductive technologies. With a reported incidence of 1-5% in its moderate and severe forms, it can be life-threatening with 1.9% cases needing hospitalization. Although there is no agreed upon definition; the disorder is characterized by marked cystic ovarian enlargement, fluid shifts from intravascular compartment resulting in ascites and hydrothorax, electrolyte imbalance, hemoconcentration, hypercoagulation and impaired renal perfusion. Risk factors for ovarian hyperstimulation syndrome include young age, a history of ovarian hyperstimulation, polycystic ovary syndrome or characteristics of polycystic ovarian syndrome. Our patient is a 29-year-old, G2P0+1 who was referred to our tertiary center as a case of severe ovarian hyperstimulation syndrome. She had undergone in vitro fertilization 18 days prior to her presentation in a private institute. She has received gonadotropins and human chorionic gonadotropin in her treatment cycle. Her vulvar edema was managed with ice packs and local myrrh which was dissolved in warm water and applied locally. The resolution was within 2 days. Patient was also kept in Trendelenburg position to help decrease the swelling. She gradually improved and was able to mobilize. She was discharged home after one week in a good general stable condition.

Chair

Dusan Vesović

Center for Integrative Procedures and Supplements, Serbia

Chair

Subramaniam Ganesh

Indian Institute of Technology, India

Chair

Dania Al-Jaroudi

King Fahad Medical City, Saudi Arabia