Day 2 :
Keynote Forum
Giulio Maria Pasinetti
Icahn School of Medicine, USA
Keynote: Mechanisms of neuroresilience to promote successful healthy cognitive and psychological aging across the lifespan
Time : 09:00-09:45
Biography:
Giulio Maria Pasinetti is The Saunders Family Chair, a Professor of Neurology, Psychiatry, and Geriatrics and Adult Development and the Director of the Center for Molecular Integrative Neuroresilience (CMIN) at the Icahn School of Medicine at Mount Sinai (ISMMS) in New York, USA.
Abstract:
Recent evidence provides support for the novel roles of the gut-microbiome/brain axis in the prevention of mood and brain degenerative disorders. It has also been shown that recently developed brain bioavailable polyphenolic compounds may help to prevent stress-induced illnesses in mice. In this presentation, Dr. Pasinetti, will discuss how psychological stress may negatively influence the normal relationship between the body and the gut microbial community ultimately impairing brain synaptic functions. Most importantly, Dr. Pasinetti’s laboratory found that stress may disrupt the gut-microbiome/brain axis through mechanisms involving altered immune-inflammatory responses. This new evidence has important ramifications especially in view of the fact that human gut microbes are able to influence the bioavailability of brain penetrating polyphenolic acids, which engage in the brain limbic regions, which are involved in mood disorders and cognitive impairment. These findings pave the road to new studies to further develop microbiome and immunoregulation-based strategies to promote resilience against psychological stress-mediated mood disorders across the lifespan.
Keynote Forum
Ben Bao Qi Cao
Hygieia Clinic, Canada
Keynote: On Complementary Traditional Chinese Medicine with Conventional Modern Medicine Each Other
Time : 09:45-10:30
Biography:
Ben Bao Qi Cao is currently working at Hygieia Clinic, College of Traditional Chinese Medicine Practitioners and Acupuncturists of British Columbia. He is the committee member of Canadian Alliance of Regulatory Bodies of Traditional Chinese Medicine; Vancouver, Canada His research interest includes Acupuncture, Traditional Chinese Medicine and Integrative medicine.
Abstract:
The research object of Traditional Chinese Medicine (TCM) and Conventional Modern Medicine (CMM) is the same, human body, their purpose is to help human to treat disease or injury and care health. However they are products in two different historical backgrounds. TCM is born before the development of modern science, while the CMM is the product of the birth of modern science. Therefore, from the basic theory to clinical practice, both are very different. They have the two different ways of thinking: TCM had to use a comparative comprehensive approach and CMM use the way of inductively analysis. The two have different views on the body, TCM is more focused on the course of the evolution of life and CMM is more focused on the outcome of the evolution of life. The two methods of research are completely different, TCM consider the unity of heaven and man as an organic whole from the macro point of view and pay attention to the interaction between the various parts of the body and the impact of nature on the body; CMM consider the body as a combination of parts using the analysis method from the micro of view, its research is deep and nuanced. The two methods of diagnosis are different. TCM is still used for inspection, auscultation and olfaction, interrogation, pulse diagnosis and body palpation. CMM more and more rely on advanced medical equipment. The treatment strategy is different, TCM is a balanced medicine, pays attention to the patient with diseases, at full steam improve the patient's own resistance to the disease, while trying to give way to the evil; CMM is against medicine, pays attention to the diseases of the patient, try to help patients eliminate the disease. The two treatment methods are different, TCM use compound Chinese medicine (formula) applying the theory of Monarch, Minister, Assistant and Guider in order to increase efficacy and less side effect. As long as the syndrome differentiation is accurate, the treatment’s reaction likes as rafter drum effect. CMM using pure chemical drugs whose structure is clear, the role of a single target, the effect is indeed. The both medicine like the two opposite polar region, but each has its own merits, is just complementary to each other. Our mission is to let the two to communicate first and then to open up the 21st century new integrate medicine.
Keynote Forum
Faryal Luhar
Pinnacle of Health - Naturopathic Wellness Centre, Canada & SA
Keynote: Importance of the Gut Microbiome for Optimal Health Outcomes in Metabolic Diseases
Time : 10:30-11:15
Biography:
Faryal Luhar, ND is a licensed Naturopathic Doctor and graduated from the Canadian College of Naturopathic Medicine in Toronto. She pursued this field of study after receiving her Bachelor’s degree in Psychology. She is a member of the Ontario Association of Naturopathic Doctors. Dr. Luhar is also registered to practice
Naturopathic Medicine in South Africa and is a member of the Allied Health Professions Council of South Africa, as well as the South African Naturopathic Association.
Abstract:
Microbes existed on earth long before humans. Single-celled bacteria living in or on the human body outnumber human cells; the American Academy of Microbiology putting human cells at 37 million, compared to 100 trillion cells of the microbiome. This co-existence between the human self and his/her intestinal microbiota is vital for optimal health; the extensive population and diversity of the microflora playing a crucial role in one's genetic expression, immune function, body weight and composition and even mental health. Ongoing research on the human microbiome reinforces the notion that humans live in symbiosis with a diverse microbial population; how this affects health and disease is an important question. The microbiome composition varies between healthy individuals and those afflicted with numerous diseases. A flurry of scientific research has implicated these microbes as having a significant role in digestive disorders as well as the development of obesity, diabetes, cardiovascular disease and even cancer. The role of inflammation in the pathogenesis of these diseases is well-recognized. Inflammatory markers and metabolic endotoxemia are increased in obesity, diabetes and insulin resistance, and cardiovascular disease and the gut is the primary point of entry for modifying these inflammatory states. The gut microbiota is being recognized as a separate endocrine organ capable of crosstalk with the host, thereby influencing health or disease. The human microbiome is now viewed to be a counterpart to the human genome. Important considerations in addressing dysbiosis to reduce or resolve the incidence of these diseases include toxic foods, overuse of antibiotics, environmental factors, pharmaceutical medications (PPIs, NSAIDs) and others. Developing a healthy gut flora begins with vaginal childbirth and breastfeeding. A healthy diet to reduce inflammation and oxidative stress, stress management and the use of probiotics are other essential factors that beneficially influence the internal ecology to improve health outcomes. The loss of microbial diversity is also linked to urbanized living and reconnecting with nature may play a significant role in health and disease outcomes.
- Ayurveda & Homeopathy | Acupuncture | Physical Therapies | Physical Therapies and Natural Remedies | Herbal Medicine and Plant Remedies | Naturopathic Medicine
Location: Salon V
Chair
Pierluigi Pompei
University of Camerino, Italy
Session Introduction
Slobodan Dunjić
Center for Integrative Procedures and Supplements, Serbia
Title: Personal-holistic approach should be used additionally to conventional therapy in treatment of colorectal cancer – case report
Biography:
Slobodan Dunjic is a Medical Doctor, completed his Master of Science in the field of Rheumatology. He is the Founder of the Center for Integrative Procedures and Supplements “Dr Dunjić”, based in Belgrade, Serbia. In professional career, he is primarily oriented towards personal and holistic approach in healing the patients suffering from various diseases. He strongly believes that we need to treat a person suffering from diseases, rather than disease itself. He is also the Co-Founder of association for personal holistic approach in healing the patients in Serbia and by activity of this association; he provides continuing medical education to all medical professionals. He has published more than 25 papers in various journals at national and international level.
Abstract:
For the great majority of people, the major factor that increases a person’s risk for colorectal cancer is increasing age. Risk increases dramatically after age 50 years and 90% of all colorectal cancers are diagnosed after this age. The risk factors are numerous such as the history of colorectal cancers in first-degree relatives, presence of adenomas, ovarian cancer, inflammatory bowel disease etc. The aim of this paper is to present a case report showing that personal holistic approach in treatment of colorectal cancer additionally to standard therapy resulted in excellent outcome. 34 year old female patient noticed changes in bowel movements and the presence of blood in the stool during March of 2016. Immediately she visited her doctor. All necessary examinations were done (laboratory test, physical exam, digital rectal exam, fecal occult blood exam and colonoscopy). Adenocarcinoma of rectum which invaded submucosa was diagnosed. CT scan and magnetic resonance imaging (MRI) revealed enlarged lymphatic nodes in pelvic region with no presence of distant metastasis. 25 cycles of irradiation and 2 cycles of chemotherapy were administered. Following that, she was told she would be operated. Additionally to this treatment, she was subjected to personalized holistic treatment in three phases: (1) Detoxification of body, (2) Supplementation with minerals/trace elements/omega-3 fatty acids etc., and (3) Improving lymphatic circulation. Muscle test was applied in order to determine if the body needs supplements and which one (this ensures that every person has its own therapy which is personally tailored according to his/her body needs and current health status). While irradiation and chemotherapy, she did not report significant side effects described in the literature. She was scheduled for operation during mid of November, 2016. All the exams done before the operation showed that there was no cancer and she was dismissed with no operation. This is an example how personal holistic approach used concomitant with standard therapy may be useful in treatment of cancer patients.
Dušan Vešović
Center for Integrative Procedures and Supplements, Serbia
Title: Personal-holistic approach in treatment of breast cancer additionally to conventional therapy – case report
Biography:
Dusan Vesovic is a Medical doctor possessing Doctorate of Medical Sciences in the field of Preventive Medicine (Occupational Medicine). He also works as the Professor of Occupational Medicine. He is orientated towards personal holistic approach in treating the patients. He deeply believes that the disease is a result of imbalance in human body and when we treat a patient, we need to re-establish homeostasis in his/her body. For that purpose, he believes that personalized therapy of whole body, including spirit and mind should be applied. He is also the Co-Founder of association for personal holistic approach in healing the patients in Serbia and by activity of this association; he provides continuing medical education to all medical professionals. He has published more than 100 papers in various journals at national and international level.
Abstract:
Nowadays, breast cancer is the second leading cause of cancer death in women (the first one is lung cancer). The chance that a woman will die from breast cancer is about 1 in 36 (about 3%). The aim of this paper is to present case-report showing that personal-holistic approach in treatment of breast cancer additionally to standard therapy resulted in excellent outcome. 54 year old female patient noticed changes in skin of left breast during spring time of 2015. Immediately she visited her doctor. All necessary examinations were done (laboratory test, physical exam, chest X-ray, ultrasound, scintigraphy, etc.). Upon biopsy, diagnosis of ductal mixed invasive carcinoma was established. Scintigraphy revealed distant metastasis in spine, bones of shoulders, jaws and bones of pelvic region. Tumor marker CA15-3 was extremely high. Patient was suggested to undergo eight cycles of chemotherapy and single shot irradiation therapy. No operation was suggested. Additionally to this treatment, she was subjected to personalized holistic treatment in three phases: (1) Detoxification of body, (2) Supplementation with minerals/trace elements/omega-3 fatty acids etc., and (3) Improving lymphatic circulation. Muscle test was applied in order to ensure that this patient will receive its own therapy which is personally tailored. While irradiation and chemotherapy, she did not have significant side effects described in the literature. Her overall health status was getting better and she was, nevertheless, operated in September of 2015. Two tumors were extracted, as well as, five tumors from Spencer flap. 17 lymph nodes from armpit were removed. All the time, she has been using conventional drugs concomitant with personalized therapy. She is well now and recent scintigraphy showed regression process in bones. This is an example how personal holistic approach used concomitant with standard therapy may be useful in treatment of cancer patients.
Subramaniam Ganesh
Indian Institute of Technology, India
Title: Neuroprotective mechanisms of Amalaki Rasayana (Ayurvedic Medicine): A study on a genetic mouse model of neurodegenerative disorder
Biography:
Subramaniam Ganesh is an Endowed Chair Professor at the Indian Institute of Technology Kanpur, has made pioneering contribution in the field by choosing to work on the fatal neurodegenerative disorder Lafora disease (LD), characterized by abnormal glycogen accumulation in neurons. His recent research interests are in elucidating the molecular basis of therapeutic properties of the Ayurvedic formulations; one of the traditional medicinal systems of India.
Abstract:
Neurodegenerative disorders have attracted a lot of attention due to their complex origin (genetic and environmental), irreversible disease progression and their increasing incident rate due to increased life expectancy as most of them are late onset disorders. Emerging concepts suggest that the neurodegeneration results from perturbations in a number of cellular processes, including the proteolytic, inflammatory, pro-survival and metabolic pathways, that they share similarities with the aging process and that restoring the homeostasis of critical cellular processes might protect the neurons. Indeed the Ayurvedic formulations, known as “Rasayanas” and “Bhasmas”, are thought to provide such holistic protection on the central nervous system, but the underlying mechanisms have not been dissected using appropriate model systems and their mode of actions are yet to be fully understood. Our group has been working on the Lafora disease (LD), a monogenic, progressive and fatal form of neurodegenerative disorder and the symptoms include epilepsy, ataxia, dysarthria, psychosis and cognitive deficits. The neuropathology of LD includes the formation of glycogen inclusions as Lafora bodies in the neurons, muscle and liver tissues. The LD animals replicate most of the phenotypic traits and studies have shown that perturbations in glycogen metabolic pathways, proteolytic pathways and mitochondrial homeostasis underlie the LD symptoms. The current work was to evaluate the effect of prolonged feeding of Amalaki Rasayana (a formulation with extracts of Emblica officinalis) on the disease phenotype (viz., epilepsy, ataxia and cognitive abilities), disease pathology (viz., Lafora bodies, neurodegeneration, neuronal growth and maturation) and on the cellular physiology (viz., glycogen metabolism, autophagy and proteasomal function, neuroinflammation and synaptic functions). We find that feeding of animals with Amalaki Rasayana significantly reduced the neuroinflamation, increased autophagy and decreased the severity of the drug-induced epilepsy in this LD model.
Chanchal Garg
Maharshi Dayanand University, India
Title: Role of Natural Antioxidants in the Oxidative Stress induced Skin Photoaging
Biography:
Chanchal Garg completed masters at MDU Rohtak (Maharshi Dayanand University) in Harayana and presently she is working as Faculty of Pharmacy, in the Department of Pharmaceutical Sciences, Maharashi Dayanand University, India.
Abstract:
An optimized ionic liquid-based microwave assisted extraction (IL-MAE) method was developed for piperine from Piper nigrum using ionic liquid, 1-butyl-3-methyl-imidazolium chloride ([bmim]Cl) by response surface methodology. Variable microwave-assisted extraction parameters were selected as concentration of [bmim]Cl, extraction time and microwave power while solid-liquid ratio and extraction temperature were kept constant. Response surface methodology was applied for developing, improving and optimizing the process. A multivariate quadratic regression equation was obtained by central composite design. The 3D response surface curve and contour plots were obtained by variance of analysis (ANOVA). HPTLC was performed for quantitative and comparative analysis of piperine for IL-MAE with conventional methods. The optimum extraction conditions were 3.0 mol/L, microwave power 700 W, extraction time 9 min, extraction temperature 70 ºC, solid- liquid ratio 1:10. With this novel IL-MAE method, the yield of piperine is increased from 1.8% w/w in 7 days (maceration) and 2.03% in 3 hours (soxhlation) to 4.71% in 9 minutes (IL-MAE). Meanwhile, there was great reduction in the environmental pollution by using the green solvents/ionic liquids (ILs), which is a great benefit to all.
Dania Al-Jaroudi
King Fahad Medical City, Saudi Arabia
Title: Myrrh for treatment of severe vulvar edema in ovarian hyperstimulation syndrome
Biography:
Dania Al-Jaroudi is currently working as a Consultant in Obstetrics and Gynecology and REI, Reproductive Endocrine and Infertility and minimally invasive surgery. She is also the Chairman of Grant Management Department at the Research Center, King Fahad Medical City, KSA. She is an Assistant Professor of King Saud Bin Abdulaziz University for Health Sciences from March 28, 2010 to till date. She has completed her MBBS from King Saud University in 1996 and her Residency training at King Fahad National Guard Hospital, Riyadh in 2001. She has obtained her Fellowship training in Reproductive Endocrine and Infertility in 2004 at McGill University in Canada. She has over 30 publications, published several articles in international peer review journals and has on-going research projects in collaboration with other physicians.
Abstract:
Ovarian hyperstimulation syndrome is an iatrogenic complication of assisted reproductive technologies. With a reported incidence of 1-5% in its moderate and severe forms, it can be life-threatening with 1.9% cases needing hospitalization. Although there is no agreed upon definition; the disorder is characterized by marked cystic ovarian enlargement, fluid shifts from intravascular compartment resulting in ascites and hydrothorax, electrolyte imbalance, hemoconcentration, hypercoagulation and impaired renal perfusion. Risk factors for ovarian hyperstimulation syndrome include young age, a history of ovarian hyperstimulation, polycystic ovary syndrome or characteristics of polycystic ovarian syndrome. Our patient is a 29-year-old, G2P0+1 who was referred to our tertiary center as a case of severe ovarian hyperstimulation syndrome. She had undergone in vitro fertilization 18 days prior to her presentation in a private institute. She has received gonadotropins and human chorionic gonadotropin in her treatment cycle. Her vulvar edema was managed with ice packs and local myrrh which was dissolved in warm water and applied locally. The resolution was within 2 days. Patient was also kept in Trendelenburg position to help decrease the swelling. She gradually improved and was able to mobilize. She was discharged home after one week in a good general stable condition.