Munish Garg
Maharshi Dayanand University, India
Title: Development and Optimization of Boswellic acids loaded proniosomal Gel
Biography
Biography: Munish Garg
Abstract
Boswellic acids (BAs) are isolated from oleo gum of Boswellia serrata Triana & Planch. (Family: Burseraceae) and are mainly used as potential anti-inflammatory, hypolipidemic, immunomodulatory and antitumor agents. Pharmacokinetic investigations of boswellic acids uncover its poor bioavailability through digestive system thus necessitates an improved
therapeutic response which can possibly be achieved by developing formulations through novel delivery system. The present study was conducted to design topical boswellic acids loaded proniosomal gel for the management of inflammatory disorders with enhanced bioavailability. Non-ionic surfactant vesicles were prepared using the coacervation phase separation method.
A central composite design was employed to statistically optimize formulation variables using Design-Expert software. Three independent variables were evaluated: Amount of surfactant (X1), amount of soyalecithin (X2), and amount of cholesterol (X3). The encapsulation efficiency percentage (Y1) and particle size (Y2) were selected as dependent variables. The optimum
formulation (F10) displayed spherical bi-layered vesicles under transmission electron microscopy (TEM) with optimum particle size of 707.9 nm and high entrapment efficiency as 98.52%. In vitro skin permeation study demonstrated the most sustained release of 84.83±0.153 mg/cm2 in 24 hours. Antiinflammatory activity of the gel showed a significant (p<0.001)
higher percentage inhibition as compared to the marketed gel at the same dose. The present study exhibited that boswellic acids loaded proniosomal gel was better in terms of absorption, bioavailability and release kinetics.