Day 1 :
Keynote Forum
Thomas Bayne
Microbiome Labs, USA
Keynote: Thirty days of multi-strain probiotic supplementation was associated with reduced incidence of post-prandial dietary endotoxin, triglycerides, and disease risk biomarkers
Time : 09:30-10:30
Biography:
Thomas Bayne is a Chiropractic Physician who specializes in nutritional therapies and is an International Expert in digestive health and detoxification. His philosophy addresses the relationship between structure and function of the human body and how that translates into your best health. He has over 20 years of experience in natural health and medicine. His passion for holistic medicine led him to Europe, where he had executive roles at two top natural health companies. As International Marketing Director for one of Europe’s leading food supplement manufacturers, his responsibilities included formulating supplements based on specific patient conditions, lecturing on his clinical experiences, research that supported natural medicines and developing educational materials for physicians and pharmacies. His 20 years of clinical experience combined with his extensive knowledge in product development has led to the development of MegaSporeBiotic®.
Abstract:
Dietary or metabolic endotoxemia is a condition that affects approximately 1/3 of individuals living in Western society. It is characterized by increased serum endotoxin concentration during the first five hours of the post-prandial period following consumption of a meal with a high-fat, high-calorie content. Long-term repeated dietary endotoxemia may increase the risk of developing a variety of chronic diseases. Of the available treatments, oral probiotic supplementation has been purported to reduce gastrointestinal permeability to endotoxin, which in theory should suppress the dietary endotoxin response. The purpose of this study was to determine if 30 days of oral probiotic supplementation could reduce post-prandial dietary endotoxemia in responder subjects. Apparently healthy men and women (N=75) were screened for post-prandial dietary endotoxemia. Subjects whose serum endotoxin concentration increased by at least 5-fold from pre-meal levels at 5-hours post-prandial were considered responders and were randomized to receive either placebo (rice flour) or multi-strain probiotic supplement (Bacillus indicus (H36), Bacillus subtilis (H58), Bacillus coagulans, and Bacillus licheniformis, and Bacillus clausii) for 30 days. The dietary endotoxemia test was repeated at the conclusion of the supplementation period. Dietary endotoxin (LAL) and triglycerides (enzymatic) were measured using an automated chemistry analyzer. Serum disease risk biomarkers were measured using bead-based multiplex assays as secondary exploratory measures. Data were statistically analyzed using repeated measures ANOVA and P<0.05. We found that probiotic supplementation was associated with 42% reduction in endotoxin (P=0.011) and 24% reduction in triglyceride (P=0.004) in post-prandial period Placebo subjects presented with 36% increase in endotoxin and 5% decrease in triglycerides over the same post-prandial period. We also found that probiotic supplementation was associated with significant post-prandial reductions in IL-12p70 (P=0.017), IL-1b (P=0.020) and ghrelin (P=0.017) compared to placebo subjects. The key findings of the present study were that oral probiotic supplementation reduced responses that were consistent with leaky gut syndrome and transient reductions in chronic/metabolic disease risk.
Keynote Forum
Lloyd Jenkins
Budwig Cancer Clinic, Spain
Keynote: Transcript for Presentation at Holistic Natural Health Seminar
Time : 10:30-11:15
Biography:
Lloyd Jenkins has completed his BA with Warnborough University of England, UK and his Master’s in Education and Doctorate in Natural Health Sciences was completed with St. Petersburg State University. He has graduated cum laude with a major in Cancer Research to earn his PhD. He is a Naturopathic Doctor who has written seven books on natural health and emotional wellbeing and several articles for a local newspaper on complementary health subjects and has been interviewed several times on radio stations in USA and Spain.
Abstract:
Cancer has reached such portions now that Medical News Today stated that in the USA alone 1 in 2 women and 1 in 3 men will develop cancer in their lifetime. What has changed in the past 100 years that so many are getting cancer? The answer is basically because we are now literally living in a toxic soup. In North America alone, there are more than 77,000 chemicals being produced with more than 3,000 chemicals added to our food supply and more than 10,000 chemicals in the form of solvents, emulsifiers and preservatives that are used in food processing, packaging, wrapping and storage. 3000 chemicals can be found in one cigarette. The EPA estimates there are more than 20,000 chemicals that our bodies cannot metabolize causing untold damage. In addition our bodies are assaulted by electrical pylons and cell phone tower frequencies on a constant basis. Our environment also exposes us up to dangerous xenoestrogens (xeno meaning foreign) from the chemical estrogens all around us. Things like herbicides, pesticides, the amalgam (silver) fillings in our teeth, antiperspirants and certain types of plastics, such as thin cling wrap type of plastics people often use to wrap their sandwiches and foods in, to name just a few. The late Dr. Hulda Clark who specialized in treating cancer found that her patients had isopropyl alcohol in their liver and she considered this industrial rubbing alcohol as one of the major toxins causing cancer.
- Current Research in Alternative Medicine | Holistic Approach of Alternative Medicine | Herbal Medicine and Plant Remedies | Evolution of Alternative Medicine
Location: Salon V
Chair
Lloyd Jenkins
Budwig Cancer Clinic, Spain
Session Introduction
Zehra Gok Metin
Hacettepe University, Turkey
Title: Aromatherapy and refl exology experiences of Rheumatoid Arthritis patients
Biography:
Zehra Gok Metin has completed her PhD in 2015 from Hacettepe University and stayed almost one year at University of Alabama at Birmingham for Post-doctoral studies. She is an Instructor at Hacettepe University Faculty of Nursing. She is working on symptom management especially for pain for five years. She has several publications in reputed journals and has been serving as a reviewer for reputed journals.
Abstract:
Statement of the Problem: Nonpharmacological interventions such as aromatherapy and reflexology have increasingly been used to manage symptoms among patients with rheumatoid arthritis (RA). There have been quantitative studies, have shown that aromatherapy and reflexology may reduce psychological distress and enhance symptom control in RA patients). However, little is known about the personal meanings patients associate with these therapies. Therefore, present study explored the patients' experiences of aromatherapy and reflexology by using face to face interview. Methodology & Theoretical Orientation: Totally 34 RA patients who received aromatherapy massage (n=17) or reflexology (n=17) constituted the study sample. “Patients’ demographic questionnaire” and “Individual experiences form for aromatherapy and reflexology” were used to record patients’ statements during face to face interviews. Patients’ statements on aromatherapy and reflexology were categorized based on similarity and presented by using percentages. Findings: Patients’ mean age was 54.4±1.2 years and the great majority of the patients were female (88.2%). Regarding patients’ experiences on aromatherapy, all subjects stated that walked more easily, wanted to sleep immediately after each aromatherapy session, felt more comfortable, 94.1% of patients’ had relief of daily functions and movements, felt improvements in vitality, energy capacity and mood. 76.5% of participants stated return to hobbies and activities they enjoy after aromatherapy sessions. As for reflexology, all participants reported that return to hobbies and activities they enjoy, felt improvements in vitality, energy capacity and mood. 94.1% of patients’ stated that walked more easily, 88.2% had relief of daily functions and movements, and 82.4% fulfilled house work without difficulty. Conclusion & Significance: Consistent with studies reporting cancer patients’ perceptions, RA individuals in this study specified that aromatherapy and reflexology had beneficial effects to perform their activities of daily living easily, felt self-empowered, having lower symptom burden, and depressive mood.
Tu Feng
School of Chinese Medicine Hong Kong Baptist University, Hong Kong
Title: Comparison of Effectiveness of Acupuncture thrust-debonding and three Acupoints in Patients shoulder with Subacromial impingement syndrome: A Randomized Clinical Trial
Biography:
Tu Feng, Principal Lecturer of the Teaching and Researching Division, School of Chinese Medicine. Feng Tu won President’s Award for Outstanding Performance
in Teaching.
Abstract:
Objective: To explore therapeutic effect of acupuncture in treating Subacromial Impingement Syndrome (SIS), through the
comparison of effectiveness of thrust-debonding and three acupoints in patients shoulder.
Method: It is a randomized clinical trial. This study was carried out with 40 patients, who had SIS. Observation group (n=20)
had received needle thrust-debonding program in subacromial space, Control group (n=20) was treated with needling three
acupoints, which are Jianyu (LI 15), Jianliao (SJ 14), Tianzong (SI 11). All patients received one treatment sessions for four
weeks (once a week).
Outcome Measures: The effects were observed after four weeks of treatment, according to the standard of TCM Syndrome
Diagnostic efficacy. Pain was evaluated using Constant-Murley Score (CMS) for 1st, 2nd and 4th week.
Results: Cure rate after 4 weeks in observation group was 90%, higher than 55% in control group with statistical meaning
(P<0.05). The treatment program of observation group were found to be significantly effective in reduction of pain with CMS
(P<0.05) in different period before and after treatment, but the control group showed no significantly effective (P>0.05).
Conclusion: The results of this clinical trial demonstrate that the thrust-debonding program may be the first treatment choice
for therapist in managing SAIS.
Chanchal Garg
Maharshi Dayanand University, India
Title: Optimized Ionic Liquid-based Microwave Assisted Extraction of Piperine from Indian Ayurvedic Plant Piper nigrum
Biography:
Chanchal Garg completed masters at MDU Rohtak (Maharshi Dayanand University) in Harayana and presently she is working as Faculty of Pharmacy, in the Department of Pharmaceutical Sciences, Maharashi Dayanand University, India.
Abstract:
An optimized ionic liquid-based microwave assisted extraction (IL-MAE) method was developed for piperine from Piper nigrum using ionic liquid, 1-butyl-3-methyl-imidazolium chloride ([bmim]Cl) by response surface methodology. Variable microwave-assisted extraction parameters were selected as concentration of [bmim]Cl, extraction time and microwave power while solid-liquid ratio and extraction temperature were kept constant. Response surface methodology was applied for developing, improving and optimizing the process. A multivariate quadratic regression equation was obtained by central composite design. The 3D response surface curve and contour plots were obtained by variance of analysis (ANOVA). HPTLC was performed for quantitative and comparative analysis of piperine for IL-MAE with conventional methods. The optimum extraction conditions were 3.0 mol/L, microwave power 700 W, extraction time 9 min, extraction temperature 70 ºC, solid- liquid ratio 1:10. With this novel IL-MAE method, the yield of piperine is increased from 1.8% w/w in 7 days (maceration) and 2.03% in 3 hours (soxhlation) to 4.71% in 9 minutes (IL-MAE). Meanwhile, there was great reduction in the environmental pollution by using the green solvents/ionic liquids (ILs), which is a great benefit to all.
Munish Garg
Maharshi Dayanand University, India
Title: Development and Optimization of Boswellic acids loaded proniosomal Gel
Biography:
Munish Garg is presently working as a Professor and Head of the Department of Pharmaceutical Sciences, Maharshi Dayanand University, India. He has about 17 years of professional experience in the field of Academics, Research and Administration. Previously he has worked as an Assistant Director, All India Council for Technical Education, New Delhi where he has contributed in the quality control of technical education. His research area is Quality Control and Standardization of Herbal Plants and Formulations for Safety and Efficacy. He has about 70 research papers, 50 presentations, 150 scientific abstracts and financial grant of about Rs. 1 Crore from different Government funding agencies to his credit. He is in the panel of several Government bodies for planning and execution of pharmacy and technical education in India.
Abstract:
Boswellic acids (BAs) are isolated from oleo gum of Boswellia serrata Triana & Planch. (Family: Burseraceae) and are mainly used as potential anti-inflammatory, hypolipidemic, immunomodulatory and antitumor agents. Pharmacokinetic investigations of boswellic acids uncover its poor bioavailability through digestive system thus necessitates an improved
therapeutic response which can possibly be achieved by developing formulations through novel delivery system. The present study was conducted to design topical boswellic acids loaded proniosomal gel for the management of inflammatory disorders with enhanced bioavailability. Non-ionic surfactant vesicles were prepared using the coacervation phase separation method.
A central composite design was employed to statistically optimize formulation variables using Design-Expert software. Three independent variables were evaluated: Amount of surfactant (X1), amount of soyalecithin (X2), and amount of cholesterol (X3). The encapsulation efficiency percentage (Y1) and particle size (Y2) were selected as dependent variables. The optimum
formulation (F10) displayed spherical bi-layered vesicles under transmission electron microscopy (TEM) with optimum particle size of 707.9 nm and high entrapment efficiency as 98.52%. In vitro skin permeation study demonstrated the most sustained release of 84.83±0.153 mg/cm2 in 24 hours. Antiinflammatory activity of the gel showed a significant (p<0.001)
higher percentage inhibition as compared to the marketed gel at the same dose. The present study exhibited that boswellic acids loaded proniosomal gel was better in terms of absorption, bioavailability and release kinetics.