16^thInternational Conference on Frontiers in Alternative & Traditional Medicine August 24-25, 2021 Singapore City, Singapore

Biography:

Chaachouay N has completed his/her PhD at the age of 30 years from FSK University, Morocco. He is the Associate professor of Hassan first University, Morocco. He has over 15 publications that have been cited over 93 times, and his publication H-index is 4.

Abstract:

Introduction: Coronaviruses are important animal and human pathogens. Towards the end of 2019, the novel coronavirus identified in Wuhan, China, presented as a cluster of symptoms of pneumonia. Its quick spread resulted in a global pandemic. This research documents detailed ethnopharmacological information on the medicinal plant species used by herbalists against coronavirus disease.

Methods: The study was conducted in Salé Prefecture, from March 1st, 2020 to May 31st, 2020. Semi-structured face to face interviews were held with 30 herbalists and collected; socio-demographic characteristics, the names of local species, and traditional remedies being used. The data were analyzed through the use reports (UR) and medicinal use value (MUV).

Results: In total, 20 plant species from 20 genera and 14 families had been most frequently used by herbalists from Salé Prefecture for the prevention and treatment of COVID 19. The most mentioned plant was Eucalyptus globulus Labill., followed by Azadirachta indica A. Juss,. and Ziziphus lotus (L.) Lam. Moreover, the most commonly used plant parts for herbal preparations were leaves (28.43%) and seeds (17.5%), and the majority of remedies were prepared through infusion.

Conclusions: The present study is the first contribution to the ethnopharmacological profile of this Prefecture. It is recommended that the constituents of indigenous species be studied to determine the therapeutic effects and mechanisms of action. However, attention must be paid to the conservation of medicinal species, comprehensively documenting traditional medicinal knowledge as well as conducting phytochemical validation of reported plants.

Biography:

Abstract:

Skin is one of the most sensitive parts of the body and is  important to maintain the beauty of man. Herbal products  have fewer side effects than chemicals and have  pharmacological effects on the skin, so are used in cosmetic preparations. Books, articles and electronic databases including ISI Web of Science, PubMed, Magiran and IranMedex were searched to  identify plants with positive effects on the skin, regardless of  adverse effects and their interactions.  A number of plants which were used in the treatment of skin  diseases and their effects had been established, were chosen  and reviewed. Avocado, thyme, aloe vera, chamomile,  almond, licorice, calendula, olive and yarrow were included in  this review.  There are many herbs that have a role in the prevention and  treatment of skin diseases, and are used in either traditional  medicine or the preparation of cosmetics. The effects of a  number of them have been scientifically proved and this  information for the production of cosmetic and  pharmaceutical products can be used.

Biography:

Prof. Samra Bashir, Faculty of Pharmacy, Capital University of Science and Technology, Kahuta Road, Islamabad Expressway, Zone V, Islamabad

Abstract:

Back ground: The horse purslane, Trianthema portulacastrum, Linn. (Aizoaceae), is used in traditional systems of medicine for the treatment of asthma. The current investigation was aimed at exploring possible mechanisms underlying the potential bronchodilator effect of Trianthema portulacastrum (T. portulacastrum).

Methodology: The whole plant extract of T. portulacastrum prepared in 70% (v/v) aqueous-methanol was studied on carbachol-induced bronchoconstriction in anaesthetised rats for its in-vivo bronchodilator activity and on isolated rabbit trachea, to find out the mechanistic basis of the therapeutic effect. The data were analysed using Student’s t-test.

Results: T. portulacastrum crude extract dose-dependently (3 - 30 mg/kg) inhibited carbachol-induced bronchoconstriction in anaesthetised rats, similar to the standard bronchodilator drug, aminophylline. When tested on rabbit trachea, the plant extract inhibited carbachol (1 µM) and high K⁺ (80 mM)-induced contractions in a fashion similar to dicyclomine, indicating the presence of airway-relaxant activity, possibly mediated through blockade of calcium channels and muscarinic receptors. The presence of a dual muscarinic and Ca²⁺ channel inhibitory mechanism was confirmed when the crude extract, caused a rightwards shift of carbachol and Ca²⁺ concentration-response curves, similar to dicyclomine.

Conclusion: This investigation indicates that the T. portulacastrum extract possesses bronchodilator activity that is possibly mediated through a combination of an anti-muscarinic effect and calcium channel blockade, providing a scientific basis for its medicinal use in asthma.

Biography:

Abstract:

Recent studies have suggested effective prevention of myocardial infarction (MI) with many herbal medicines as add on therapy to the standard aspirin (Asp) therapy. Hence, the present study was designed to investigate the cardioprotective effects of Asp, chlorogenic acid (CGA) or their combination on isoproterenol (ISO) induced MI in rats. Markers of apoptosis, autophagy and oxidative stress, along with histopathological evaluation were assessed in myocardial and liver tissue sections. Serum levels of aspartate transaminase, creatine kinase, lactate dehydrogenase and cardiac troponin I were examined. The effects on the AMP-activated protein kinase (AMPK) - mammalian target of rapamycin (mTOR) pathways as potential molecular targets were also explored. Results of this study clearly revealed that CGA significantly lessened the injurious effects of ISO on the myocardium, the mixture of Asp (30mg/kg/day) and CGA (40mg/kg/day) was significantly more effective in ameliorating both the myocardial tissue pathological alterations and the serum diagnostic cardiac markers of MI as compared to either the CGA or Asp monotherapy, in addition of showing liver protective effects. Incorporating wholly the multiple effects of CGA including antioxidant, anti-inflammatory, anti-apoptosis, antifibrotic and autophagy enhancement may explain the marked cardioprotection observed in the present study. Consequently, CGA could be nominated as a promising prophylactic therapy for patients who are at risk of developing MI and to provide cardioprotection against the progression of existent diagnosed infarction.

Biography:

Dr. Dilip Ghosh has received his PhD in biomedical science from India & post-doc from USDA-ARS, HNRCA at Tufts University, Boston. He is an international speaker, facilitator and author and professionally associated with Nutriconnect, & Trigonella Labs, Australia; Adjunct-Industry Fellow, NICM Health Research Institute, Western Sydney University. He is a fellow of American College of Nutrition (ACN), professional member of Australian Institute of Food Science & Technology (AIFST), an advisor and executive board member of Health Foods and Dietary Supplements Association (HADSA), & The Society for Ethnopharmacology, India (SFE-India) and also in editorial board of several journals. His research interest includes oxidative stress, bioactive, clinically proven functional food and natural medicine development, regulatory and scientific aspects of functional foods, nutraceuticals and herbal medicines.

Dr. Ghosh has published more than 100 papers in peer reviewed journals, numerous articles in food and nutrition magazines and books. His most recent two books, “Pharmaceutical to Nutraceutical: A Paradigm shift in disease prevention” & “Natural Medicines-Clinical efficacy, Safety and Quality” under CRC Press, USA has been published in 2017 & 2019. His latest book, “Nutraceutical in Brain Health & beyond” is just published by Elsevier/Academic Press.

Abstract:

Cinnamon (Cinnamomum verum; C. zeylanicum) is a small evergreen tree, 10-15 meters tall, belonging to the family Lauraceae, native to Sri Lanka and South India. These plants are economically important due to their broad uses in the food and pharmaceutical industries. Cinnamon has been explored for medicinal use in the last decade; this presentation will discuss its journey in different health domains. Cinnamon consists of a variety of resinous compounds, including cinnamaldehyde, cinnamate, cinnamic acid, and numerous essential oils. The health benefits of cinnamon in clinical situations have been explored over the last decade. Numerous in vitro and in vivo studies in animals and humans have demonstrated an array of beneficial health effects, such as anti-inflammatory, anti-microbial, reducing cardiovascular disorders, boosting cognitive function, and reducing risk of colonic cancer. But there is still a lack of well-designed, randomized, placebo-controlled trials (RCTs) to substantiate these in vitro and animal results. A few recent well-designed RCTs in allergic rhinitis and chemotherapy-induced weight loss and alopecia strengthened understanding of the medicinal properties of cinnamon.

Cinnamon bark research has moved many miles ahead from culinary use as a spice and traditional medicinal use. Several of its medicinal properties and safety are now validated through modern scientific methods. These include anti-diabetic, anti-inflammatory, cardioprotective, and neurological disorders. The true multifaceted clinical potential of cinnamon polyphenols has surfaced only recently with clinical evidence for immune/allergic inflammatory conditions such as allergic rhinitis and chemotherapy side effects.