Sung-Eun Jeong
Resercher
Title: Effects of Pyungwi-san on the production of inflammatory cytokines in LPS-treated rats
Biography
Seong-Ho Ham has completed his PhD from Department of Pharmacy, Wonkwang University in 1994. He has published more than 10 papers in reputed journals and has been serving as an Editorial Board Member of repute. He worked in pharmaceutical company related Traditional Korean Medicine as a General Manager for 20 years. Currently, he is the executive manager in the Department of Traditional Korean Medicine Promotion of the upper institute. He is leading the Traditional Korean Medicine Standardization Working Group, investigating the pharmacologic and pharmacokinetic mechanisms of Traditional Korean Medicine.
Abstract
Pyungwi-san (PWS), Traditional Korean Medicine, has been used for the treatment of gastrointestinal diseases such as acute gastritis, gastric atony, anorexia, abdominal distension. PWS composed with 6 herbs, Atractylodis Rhizoma, Citri unshius Pericarpium, Glycyrrhizae Radix et Rhizoma, Magnoliae Cortex, Zingiberis Rhizoma, and Zizyphi Fructus. In this study, we tested that the anti-inflammatory effects of PWS, which was standardized by 7 components; glycyrrizic acid, rutin, liquiritin, isoliquiritin apioside, hesperidin, atractylenolide III, and honokiol from HPLC finger print analysis. PWS was administrated from 218 mg/kg to 3,270 mg/kg orally and then LPS (5mg/kg) was injected intraperitoneally to each rats after 1 hour. Animals were sacrificed after 5 hours to measure inflammatory cytokines in plasma by ELISA. LPS induced the production of inflammatory cytokines such as TNF-α, IL-1, IL-6, and PGE2 in plasma. However, PWS inhibited the production of TNF-α, IL-1, IL-6, and PGE2 following dose-dependence. Pretreatment of PWS prevented the inflammatory response in the HCl/ethanol-induced gastric mucosal injury rat model, too. These results indicate that this standardized-PWS exerts potent anti-inflammatory activity against the acute gastritis by LPS and HCl/ethanol.
Su-Ryun Kim
Researcher
Title: Reliability, Accuracy, and Use Frequency of Evaluation Methods for Amount of Tongue Coating
Biography
Su-Ryun Kim, MD(D.K.M) graduated from the College of Oriental medicine, Sangji University in 2014. She has been on a course of master’s degree from the Department of Biofuntional Medicine and Diagnosis in the same college since 2015. Her research interest is the standardization of diagnostic method of traditional medicine, especially tongue diagnosis.
Abstract
Tongue diagnosis is used as an important diagnostic method in traditional medicine. The examination of the amount of tongue coating(ATC) is the primary point of tongue diagnosis, because tongue coating(TC) is related to the internal organs, and the ATC reflects the severity of disease. However, practitioners have used very different methods for evaluating ATC and their reliability and accuracy have been still questionable. Therefore, the aim of this study was to classify the evaluation methods for ATC and then to investigate their reliability, accuracy, and frequency of use, through reviewing previous related articles. Articles were searched for evaluation methods to assess the ATC from PubMed and the Cochrane Library. Finally, we selected 113 articles and classified the evaluation methods from these articles into four types: intuitive, specificative, computerized, and weighing TC. The reliability in the intuitive and specificative methods showed varying levels among the studies. In general, the amount of TC calculated by the specificative method was more strongly related to the directly measured value than to the value estimated by the computerized method. The number of articles published on this topic has increased consistently, and the specificative method was the most frequently used. We believe that the high prevalence of the specificative method will continue in clinical practice. However, to establish higher reliability, the limitation of the subjectivity of the assessors should be overcome through calibration training. In the computerized method, novel algorithms are needed to for higher accuracy to help the practitioners.